Pre-implantation Genetic Diagnosis is a revolutionary advancement used in concurrence with IVF which allows genetic testing of an embryo prior to implantation and before pregnancy occurs.
World renowned PGD laboratories in Spain offer the most affordable and advanced technology available to patients. This unique alliance of prominent repute and progressive technology provides couples access to expertise and the ultimate in personalised care.
Patients travel abroad from Italy, Germany, Portugal, the United Kingdom and Turkey for the most elite and expanding PGD treatment in Spain.
Currently, gender selection with PGD is illegal and is only allowed for beneficial reasons to avoid a gender-related disease.
DEFINING PREIMPLANTATION GENETIC DIAGNOSIS (PGD)
For couples at risk of having children affected by an inherited disease, Preimplantation Genetic Diagnosis (PGD) Spain is an expressly beneficial laboratory technique that allows meticulous examination of the DNA of eggs or embryos in choosing only those that meet certain characteristics and eliminating those with specific hereditary disorders.
The progressive technique of PGD can be used to test for over 100 different genetic conditions such as cystic fibrosis, fragile X syndrome, hemophilia, spinal muscular atrophy, Huntington’s disease, muscular dystrophy, and sickle-cell anaemia.
GOOD CANDIDATES FOR PGD SPAIN
PGD Spain is implemented during various fertility situations including:
- Prior unexplained IVF failure
- Conception of a chromosomal abnormal child
- Polycystic ovary syndrome
- History of ovarian hyperstimulation syndrome
- Heritable medical condition in either the patient or in a prior child (such as hemophilia)
- Premature ovarian failure or premature menopause
PGD PROCEDURE — STEP BY STEP
IVF Cycle –
PGD is performed as a part of an in-vitro fertilisation (IVF) cycle, during which multiple eggs are produced, retrieved from the ovaries, and fertilised with sperm in an embryology laboratory. IVF is necessary for the PGD procedure, because it allows access to the embryos.
Embryo Biopsy –
On day five of embryo culture, the embryos are over one hundred cells divided. One or two cells are detached from each embryo during an embryo biopsy, and a genetic assessment is performed.
The PGD technique used to examine the chromosomes is fluorescent in situ hybridisation (FISH). FISH involves labelling the chromosomes with a fluorescent tag allowing them to be examined by the embryologist. Only the healthy embryos are then transferred back into the uterus.
DETECTING DISORDERS USING PGD
Cystic Fibrosis, Sickle Cell Anaemia, Thalassemia, HLA genotyping, Epidermolysis Bullosa, Gaucher Disease, Tay-Sachs Disease, Glycogen Storage Disease, Congenital Adrenal Hyperplasia, Spinal Muscular Atrophy, and Phenylketonuria
Myotonis Dystrophy, Huntington’s disease, Polycystic Kidney Disease, Familial Adenomatous Polyposis (APC gene), Neurofibromatosis 1 and 2, Li-Fraumeni (p53 gene), Marfan syndrome, Osteogenesis Imperfecta types I and IV, Charcot-Marie-Tooth type IA, Multiple Epiphyseal Dysplasia, Retinitis Pigmentosa, and Achondroplasia
X Linked Diseases
Fragile X, Hemophilia A and B, Duchenne Muscular Dystrophy, OTC, X-linked Hydrocephalus, and Myotubular Myopathy
Chromosomal translocations and Chromosomal trisomy (Trisomy 13, 18, or 21, and Down syndrome)
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